Bacteriophages show great potential in treating patients with prosthetic joint infections, as they act synergistically with antibiotics and destroy biofilms. The journal Frontiers in Medicine published a clinical case on the treatment of a recurrent prosthetic joint infection caused by Pseudomonas aeruginosa * <\/p>\n
An 88-year-old male patient, weighing 63 kg, with a recurrent infection of the left knee prosthesis caused by Pseudomonas aeruginosa, experienced a significant deterioration of his general condition. He required bed rest due to congestive heart failure, and his C-reactive protein level was 100 mg\/l. As neither removal nor replacement of the prosthesis was possible, the patient was offered phage therapy. <\/p>\n
Three bacteriophages were selected for therapy due to their high lytic activity against the P. aeruginosa strain isolated from the patient. A clinical pharmacist extemporaneously prepared a phage cocktail in the form of a suspension (initial concentration 1 \u00d7 10^10 pfu\/ml for each phage), which was diluted to a concentration of 1 \u00d7 10^9 pfu\/ml for each phage before use. <\/p>\n
The patient underwent arthroscopy, and 30 ml of the phage preparation was injected via the arthroscope (PhagoDAIR procedure). At the same time, the patient began antimicrobial therapy, which lasted 3 weeks: Ceftazidime intravenously (IV) 6 g\/day and Ciprofloxacin 500 mg orally twice daily. During treatment, the patient’s condition rapidly improved, symptoms of congestive heart failure and knee pain disappeared, and C-reactive protein levels normalized. After 6 and 12 months, the condition of the left knee remained good, with pain-free movement and walking. <\/p>\n
Thus, a combination of phage therapy (drug administration via an arthroscope) and antimicrobial therapy can potentially be used in the treatment of patients with prosthetic joint infections.<\/p>\n
Source:
\n* Ferry T, Kolenda C, Batailler C, Gaillard R et al. Case Report: Arthroscopic “Debridement-Antibiotics and Implant Retention” with Local Injection of Personalized Phage Therapy to Salvage a Recurrent Pseudomonas Aeruginosa Knee Infection. Front Med (Lausanne) 2021, 8: 569159. doi: 10.3389 \/ fmed.2021.569159.<\/p>\n","protected":false},"excerpt":{"rendered":"
Bacteriophages show great potential in treating patients with prosthetic joint infections, as they act synergistically with antibiotics and destroy biofilms. The journal Frontiers in Medicine published a clinical case on the treatment of a recurrent prosthetic joint infection caused by Pseudomonas aeruginosa * An 88-year-old male patient, weighing 63 kg, with a recurrent infection of […]<\/p>\n","protected":false},"author":1,"featured_media":8658,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[248],"tags":[],"class_list":["post-8657","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatments"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2021\/06\/xray-Fuss.jpg?fit=540%2C720&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/pazElU-2fD","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/posts\/8657","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/comments?post=8657"}],"version-history":[{"count":0,"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/posts\/8657\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/media\/8658"}],"wp:attachment":[{"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/media?parent=8657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/categories?post=8657"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.phage.help\/en\/wp-json\/wp\/v2\/tags?post=8657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}