Les maladies h\u00e9patiques auto-immunes (MHA) repr\u00e9sentent un d\u00e9fi m\u00e9dical difficile, car il existe un nombre consid\u00e9rable de patients pour lesquels la th\u00e9rapie actuelle offre un b\u00e9n\u00e9fice discutable ou nul, alors que les effets secondaires peuvent \u00eatre graves, notamment le d\u00e9veloppement de malignit\u00e9s. Les virus bact\u00e9riens (phages) sont de plus en plus reconnus comme des immunomodulateurs qui contribuent \u00e0 l’hom\u00e9ostasie immunitaire et limitent l’inflammation. Les donn\u00e9es accumul\u00e9es sugg\u00e8rent que les phages peuvent \u00eatre utiles dans l’immunoth\u00e9rapie des MHA. Il a \u00e9t\u00e9 d\u00e9montr\u00e9 que les phages r\u00e9gulent \u00e0 la baisse l’expression et\/ou la production et l’activit\u00e9 de facteurs associ\u00e9s aux l\u00e9sions h\u00e9patiques [esp\u00e8ces r\u00e9actives de l’oxyg\u00e8ne, activation du r\u00e9cepteur de type Toll (TLR) 4, activation du facteur nucl\u00e9aire kappa B (NF-KB), <\/p>\n
A. G\u00f3rski, E. Jo\u0144czyk-Matysiak, M. \u0141usiak-Szelachowska, B. Weber-D\u0105browska, R. Mi\u0119dzybrodzki et J. Borysowski
\nPotentiel th\u00e9rapeutique des phages dans les maladies h\u00e9patiques auto-immunes
\nClin Exp Immunol. 2018 avr ; 192 (1) : 1\u20136. doi : 10.1111 \/ cei.13092 <\/p>\n","protected":false},"excerpt":{"rendered":"
Les maladies h\u00e9patiques auto-immunes (MHA) repr\u00e9sentent un d\u00e9fi m\u00e9dical difficile, car il existe un nombre consid\u00e9rable de patients pour lesquels la th\u00e9rapie actuelle offre un b\u00e9n\u00e9fice discutable ou nul, alors que les effets secondaires peuvent \u00eatre graves, notamment le d\u00e9veloppement de malignit\u00e9s. Les virus bact\u00e9riens (phages) sont de plus en plus reconnus comme des immunomodulateurs […]<\/p>\n","protected":false},"author":1,"featured_media":8131,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[252],"tags":[],"class_list":["post-8130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bacteriophages"],"jetpack_featured_media_url":"https:\/\/www.phage.help\/wp-content\/uploads\/2019\/07\/Leber.jpg","_links":{"self":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/comments?post=8130"}],"version-history":[{"count":0,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8130\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media\/8131"}],"wp:attachment":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media?parent=8130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/categories?post=8130"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/tags?post=8130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}