{"id":8327,"date":"2020-02-23T09:30:49","date_gmt":"2020-02-23T08:30:49","guid":{"rendered":"https:\/\/www.phage.help\/non-classe\/etude-sur-la-securite-de-la-therapie-par-bacteriophages-en-cas-dinfection-severe-a-staphylococcus-aureus\/"},"modified":"2020-02-23T09:30:49","modified_gmt":"2020-02-23T08:30:49","slug":"etude-sur-la-securite-de-la-therapie-par-bacteriophages-en-cas-dinfection-severe-a-staphylococcus-aureus","status":"publish","type":"post","link":"https:\/\/www.phage.help\/fr\/non-classe\/etude-sur-la-securite-de-la-therapie-par-bacteriophages-en-cas-dinfection-severe-a-staphylococcus-aureus\/","title":{"rendered":"\u00c9tude sur la s\u00e9curit\u00e9 de la th\u00e9rapie par bact\u00e9riophages en cas d\u2019infection s\u00e9v\u00e8re \u00e0 Staphylococcus aureus"},"content":{"rendered":"<p>Dans cette \u00e9tude non comparative, 13 patients hospitalis\u00e9s dans un h\u00f4pital australien pour des infections s\u00e9v\u00e8res \u00e0 Staphylococcus aureus ont re\u00e7u, par voie intraveineuse, une pr\u00e9paration conforme aux bonnes pratiques de fabrication, compos\u00e9e de trois bact\u00e9riophages Myoviridae (AB-SA01), en traitement adjuvant. AB-SA01 a \u00e9t\u00e9 administr\u00e9 par voie intraveineuse deux fois par jour pendant 14 j, et les param\u00e8tres cliniques, h\u00e9matologiques et biochimiques sanguins des receveurs ont \u00e9t\u00e9 surveill\u00e9s pendant 90 j. Le crit\u00e8re principal \u00e9tait l\u2019\u00e9valuation de la s\u00e9curit\u00e9 et de la tol\u00e9rance (c.-\u00e0-d. douleur et rougeur au point de perfusion et effets ind\u00e9sirables syst\u00e9miques tels que fi\u00e8vre, tachycardie, hypotension, diarrh\u00e9e ou douleurs abdominales, ainsi que le d\u00e9veloppement d\u2019une alt\u00e9ration de la fonction r\u00e9nale ou h\u00e9patique).  <\/p>\n<p>Aucun effet ind\u00e9sirable n\u2019a \u00e9t\u00e9 signal\u00e9, et nos donn\u00e9es montrent qu\u2019AB-SA01, administr\u00e9 de cette mani\u00e8re, est s\u00fbr en cas d\u2019infections s\u00e9v\u00e8res \u00e0 S. aureus, y compris l\u2019endocardite infectieuse et le choc septique. De futures \u00e9tudes contr\u00f4l\u00e9es seront n\u00e9cessaires pour d\u00e9terminer l\u2019efficacit\u00e9 d\u2019AB-SA01, mais aucune r\u00e9sistance aux phages ne s\u2019est d\u00e9velopp\u00e9e in vivo, et les mesures de la cin\u00e9tique bact\u00e9rienne et phagique dans des \u00e9chantillons sanguins sugg\u00e8rent qu\u2019une administration toutes les 12 heures de 10^9 unit\u00e9s formant des plaques pourrait constituer une base rationnelle pour de nouvelles \u00e9tudes. <\/p>\n<p>Traduction de la source : https:\/\/www.nature.com\/articles\/s41564-019-0634-z<\/p>\n<p>Petrovic Fabijan, A., Lin, R.C.Y., Ho, J. et al. Safety of bacteriophage therapy in severe Staphylococcus aureus infection. Nat Microbiol 5, 465\u2013472 (2020).   https:\/\/doi.org\/10.1038\/s41564-019-0634-z<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dans cette \u00e9tude non comparative, 13 patients hospitalis\u00e9s dans un h\u00f4pital australien pour des infections s\u00e9v\u00e8res \u00e0 Staphylococcus aureus ont re\u00e7u, par voie intraveineuse, une pr\u00e9paration conforme aux bonnes pratiques de fabrication, compos\u00e9e de trois bact\u00e9riophages Myoviridae (AB-SA01), en traitement adjuvant. AB-SA01 a \u00e9t\u00e9 administr\u00e9 par voie intraveineuse deux fois par jour pendant 14 j, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8328,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-8327","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2020\/02\/Infusion.jpg?fit=480%2C320&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/pazElU-2aj","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/comments?post=8327"}],"version-history":[{"count":0,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8327\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media\/8328"}],"wp:attachment":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media?parent=8327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/categories?post=8327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/tags?post=8327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}