La Soci\u00e9t\u00e9 europ\u00e9enne de rhinologie a mis \u00e0 jour les lignes directrices pour le traitement de la rhinosinusite aigu\u00eb et chronique et des polypes nasaux \u2013 EPOS 2020.
\nLe traitement par bact\u00e9riophages y a \u00e9galement \u00e9t\u00e9 mentionn\u00e9.<\/p>\n
Extrait de l\u2019EPOS 2020<\/p>\n
\u00ab \u00c9tant donn\u00e9 qu\u2019un traitement antibiotique peut ne pas \u00eatre efficace ou peut entra\u00eener des r\u00e9sistances des germes, des strat\u00e9gies th\u00e9rapeutiques alternatives contre S. aureus et d\u2019autres germes fr\u00e9quents dans le nez et les sinus paranasaux peuvent \u00eatre pertinentes. Th\u00e9oriquement, des virus capables de cibler les germes et de les tuer (appel\u00e9s bact\u00e9riophages) ont \u00e9t\u00e9 propos\u00e9s, afin de tuer m\u00eame le S. aureus multir\u00e9sistant (368). En outre, un cocktail de bact\u00e9riophages pourrait \u00e9ventuellement r\u00e9duire la formation de biofilm in vitro (369, 370). Cette approche pourrait \u00eatre mise en \u0153uvre en ciblant le m\u00e9tabolisme du fer, essentiel \u00e0 la croissance, \u00e0 la survie et \u00e0 la pathogen\u00e8se des bact\u00e9ries (371). Dans une exp\u00e9rience ex vivo sur une muqueuse de polype nasal, il a \u00e9t\u00e9 montr\u00e9 qu\u2019un bact\u00e9riophage de S. aureus pouvait tuer le S. aureus nasal naturellement pr\u00e9sent et pourrait r\u00e9duire la synth\u00e8se d\u2019IL-5 induite par S. aureus (372). Toutefois, \u00e0 ce jour, aucune \u00e9tude clinique n\u2019a \u00e9t\u00e9 men\u00e9e chez l\u2019\u00eatre humain pour les maladies des voies respiratoires, et d\u2019\u00e9ventuels probl\u00e8mes de s\u00e9curit\u00e9 doivent d\u2019abord \u00eatre abord\u00e9s. \u00bb <\/p>\n
368: 368. Zhang G, Zhao Y, Paramasivan S, et al. Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients. Int Forum Allergy. Rhinol. 2018;8:406-14.https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29240296 <\/p>\n
371. Richter K, Ramezanpour M, Thomas N, Prestidge CA, Wormald PJ, Vreugde S. Mind \u201cDe GaPP\u201d: in vitro efficacy of deferiprone and galliumprotoporphyrin against Staphylococcus aureus biofilms. Int Forum Allergy. Rhinol. 2016;6:737-43. <\/p>\n","protected":false},"excerpt":{"rendered":"
La Soci\u00e9t\u00e9 europ\u00e9enne de rhinologie a mis \u00e0 jour les lignes directrices pour le traitement de la rhinosinusite aigu\u00eb et chronique et des polypes nasaux \u2013 EPOS 2020. Le traitement par bact\u00e9riophages y a \u00e9galement \u00e9t\u00e9 mentionn\u00e9. Extrait de l\u2019EPOS 2020 \u00ab \u00c9tant donn\u00e9 qu\u2019un traitement antibiotique peut ne pas \u00eatre efficace ou peut entra\u00eener […]<\/p>\n","protected":false},"author":1,"featured_media":7239,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-8380","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/Nase-e1556906554309.jpg?fit=512%2C288&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/pazElU-2ba","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8380","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/comments?post=8380"}],"version-history":[{"count":0,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8380\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media\/7239"}],"wp:attachment":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media?parent=8380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/categories?post=8380"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/tags?post=8380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}