{"id":8802,"date":"2023-06-12T09:00:59","date_gmt":"2023-06-12T07:00:59","guid":{"rendered":"https:\/\/www.phage.help\/non-classe\/les-bacteriophages-ciblant-le-microbiote-attenuent-la-steatose-hepatique-non-alcoolique\/"},"modified":"2023-06-12T09:00:59","modified_gmt":"2023-06-12T07:00:59","slug":"les-bacteriophages-ciblant-le-microbiote-attenuent-la-steatose-hepatique-non-alcoolique","status":"publish","type":"post","link":"https:\/\/www.phage.help\/fr\/non-classe\/les-bacteriophages-ciblant-le-microbiote-attenuent-la-steatose-hepatique-non-alcoolique\/","title":{"rendered":"Les bact\u00e9riophages ciblant le microbiote att\u00e9nuent la st\u00e9atose h\u00e9patique non alcoolique."},"content":{"rendered":"<h1>Les bact\u00e9riophages ciblant le microbiote att\u00e9nuent la st\u00e9atose h\u00e9patique non alcoolique caus\u00e9e par Klebsiella pneumoniae fortement productrice d&rsquo;alcool.<\/h1>\n<p>Des \u00e9tudes ant\u00e9rieures ont montr\u00e9 que Klebsiella pneumoniae fortement productrice d&rsquo;alcool (HiAlc Kpn) dans le microbiome intestinal pourrait \u00eatre l&rsquo;une des causes de la st\u00e9atose h\u00e9patique non alcoolique (NAFLD). Compte tenu de la r\u00e9sistance antimicrobienne de K. pneumoniae et de la dysbiose caus\u00e9e par les antibiotiques, la th\u00e9rapie phagique pourrait pr\u00e9senter un potentiel pour le traitement de la NAFLD induite par HiAlc Kpn en raison de sa sp\u00e9cificit\u00e9 ciblant les bact\u00e9ries. L&rsquo;efficacit\u00e9 de la th\u00e9rapie phagique a \u00e9t\u00e9 \u00e9valu\u00e9e chez des souris m\u00e2les atteintes de st\u00e9atoh\u00e9patite induite par HiAlc Kpn. Des examens complets incluant des transcriptomes et des m\u00e9tabolomes ont r\u00e9v\u00e9l\u00e9 que le traitement par des phages sp\u00e9cifiques \u00e0 HiAlc Kpn pouvait att\u00e9nuer la st\u00e9atoh\u00e9patite caus\u00e9e par HiAlc Kpn, notamment le dysfonctionnement h\u00e9patique et l&rsquo;expression de cytokines et de g\u00e8nes lipog\u00e9niques.   <\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-39028-w\">lire le rapport complet<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Les bact\u00e9riophages ciblant le microbiote att\u00e9nuent la st\u00e9atose h\u00e9patique non alcoolique caus\u00e9e par Klebsiella pneumoniae fortement productrice d&rsquo;alcool. Des \u00e9tudes ant\u00e9rieures ont montr\u00e9 que Klebsiella pneumoniae fortement productrice d&rsquo;alcool (HiAlc Kpn) dans le microbiome intestinal pourrait \u00eatre l&rsquo;une des causes de la st\u00e9atose h\u00e9patique non alcoolique (NAFLD). Compte tenu de la r\u00e9sistance antimicrobienne de K. [&hellip;]<\/p>\n","protected":false},"author":558,"featured_media":8803,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-8802","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2023\/06\/bakteriophagen.jpg?fit=1282%2C500&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/pazElU-2hY","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/users\/558"}],"replies":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/comments?post=8802"}],"version-history":[{"count":0,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8802\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media\/8803"}],"wp:attachment":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media?parent=8802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/categories?post=8802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/tags?post=8802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}