{"id":8834,"date":"2023-10-06T16:34:46","date_gmt":"2023-10-06T14:34:46","guid":{"rendered":"https:\/\/www.phage.help\/non-classe\/les-phages-sont-surs-en-cas-dadministration-orale\/"},"modified":"2026-05-18T09:07:04","modified_gmt":"2026-05-18T07:07:04","slug":"les-phages-sont-surs-en-cas-dadministration-orale","status":"publish","type":"post","link":"https:\/\/www.phage.help\/fr\/non-classe\/les-phages-sont-surs-en-cas-dadministration-orale\/","title":{"rendered":"Les phages sont s\u00fbrs en cas d\u2019administration orale"},"content":{"rendered":"

De nombreuses \u00e9tudes pr\u00e9cliniques et cliniques ont r\u00e9cemment d\u00e9montr\u00e9 le r\u00f4le significatif de la phagoth\u00e9rapie dans le traitement des infections bact\u00e9riennes multir\u00e9sistantes. Toutefois, peu de chercheurs se sont concentr\u00e9s sur la surveillance des effets secondaires induits par les phages au cours de la phagoth\u00e9rapie. <\/p>\n

Outre l\u2019absence d\u2019effets ind\u00e9sirables, les r\u00e9actions immunologiques font \u00e9galement d\u00e9faut apr\u00e8s une administration orale de bact\u00e9riophages \u00e0 court et \u00e0 long terme. Dans cette \u00e9tude, des bact\u00e9riophages ciblant la souche XDR de Klebsiella pneumoniae ont \u00e9t\u00e9 administr\u00e9s par voie orale \u00e0 des rats Charles Foster \u00e0 des doses de 1015 PFU\/ml et 1020 PFU\/ml (encore plus \u00e9lev\u00e9es), sous forme de dose unique (dans l\u2019\u00e9tude de toxicit\u00e9 aigu\u00eb) et de dose quotidienne pendant 28 jours (dans l\u2019\u00e9tude de toxicit\u00e9 subaigu\u00eb). Un millilitre de suspension de bact\u00e9riophages a \u00e9t\u00e9 administr\u00e9 par sonde gastrique orale. Aucun effet ind\u00e9sirable n\u2019a \u00e9t\u00e9 observ\u00e9 chez les animaux de test ni chez les animaux de contr\u00f4le, et la consommation de nourriture et d\u2019eau ainsi que le poids corporel n\u2019ont que tr\u00e8s peu vari\u00e9 tout au long de la p\u00e9riode d\u2019\u00e9tude par rapport aux rats du groupe t\u00e9moin. <\/p>\n

Au 28e jour de l\u2019administration des phages, du sang a \u00e9t\u00e9 pr\u00e9lev\u00e9 pour d\u00e9terminer les param\u00e8tres h\u00e9matologiques, biochimiques et cytokiniques. Les donn\u00e9es n\u2019ont montr\u00e9 aucune diff\u00e9rence dans le profil h\u00e9matologique, biochimique et cytokinique par rapport au groupe t\u00e9moin. Lors des examens macroscopiques et histopathologiques, aucun changement significatif n\u2019a pu \u00eatre constat\u00e9 dans aucun des groupes de traitement. <\/p>\n

Les cytokines estim\u00e9es, l\u2019interleukine-1 b\u00eata (IL-1\u03b2), l\u2019IL-4, l\u2019IL-6 et l\u2019INF-gamma, se situaient dans la plage normale pendant l\u2019exp\u00e9rience. Les r\u00e9sultats sugg\u00e8rent que l\u2019administration orale d\u2019une dose \u00e9lev\u00e9e (1015 PFU\/ml) et d\u2019une dose tr\u00e8s \u00e9lev\u00e9e (1020 PFU\/ml) du cocktail de bact\u00e9riophages n\u2019a eu aucun effet ind\u00e9sirable, y compris aucun effet ind\u00e9sirable grave. De m\u00eame, l\u2019administration orale prolong\u00e9e et \u00e0 forte dose de bact\u00e9riophages n\u2019a d\u00e9clench\u00e9 aucune r\u00e9action immunologique notable. <\/p>\n

Lire la suite de l\u2019\u00e9tude ici<\/a><\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":558,"featured_media":8728,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[213],"tags":[],"class_list":["post-8834","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classe"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2022\/10\/1920x1080.jpg?fit=1920%2C1080&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/pazElU-2iu","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/users\/558"}],"replies":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/comments?post=8834"}],"version-history":[{"count":8,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8834\/revisions"}],"predecessor-version":[{"id":8889,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8834\/revisions\/8889"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media\/8728"}],"wp:attachment":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media?parent=8834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/categories?post=8834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/tags?post=8834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}