{"id":8941,"date":"2024-03-07T10:07:57","date_gmt":"2024-03-07T09:07:57","guid":{"rendered":"https:\/\/www.phage.help\/non-classe\/le-virome-intestinal-est-associe-a-des-changements-comportementaux-lies-au-stress-et-a-des-reponses-immunitaires-chez-la-souris\/"},"modified":"2026-05-18T09:07:14","modified_gmt":"2026-05-18T07:07:14","slug":"le-virome-intestinal-est-associe-a-des-changements-comportementaux-lies-au-stress-et-a-des-reponses-immunitaires-chez-la-souris","status":"publish","type":"post","link":"https:\/\/www.phage.help\/fr\/unkategorisiert\/le-virome-intestinal-est-associe-a-des-changements-comportementaux-lies-au-stress-et-a-des-reponses-immunitaires-chez-la-souris\/","title":{"rendered":"Le virome intestinal est associ\u00e9 \u00e0 des changements comportementaux li\u00e9s au stress et \u00e0 des r\u00e9ponses immunitaires chez la souris"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-32x6tg-e759e29a8e0eb5558b4bf7b3134992b3\">\n.flex_column.av-32x6tg-e759e29a8e0eb5558b4bf7b3134992b3{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-32x6tg-e759e29a8e0eb5558b4bf7b3134992b3 av_one_full  avia-builder-el-0  el_before_av_one_half  avia-builder-el-first  first flex_column_div av-zero-column-padding  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2\">\n.avia-image-container.av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2 av-styling- avia-align-center  avia-builder-el-1  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-3471 avia-img-lazy-loading-not-3471 avia_image ' src=\"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?fit=1600%2C400&ssl=1\" alt='' title='koli-bacteria'  height=\"400\" width=\"1600\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?w=1600&amp;ssl=1 1600w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=300%2C75&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=768%2C192&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=1030%2C258&amp;ssl=1 1030w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=1500%2C375&amp;ssl=1 1500w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=705%2C176&amp;ssl=1 705w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=450%2C113&amp;ssl=1 450w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-d13j8-8ec0a7dba69d9a0751db5b3f4751da33\">\n.flex_column.av-d13j8-8ec0a7dba69d9a0751db5b3f4751da33{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-d13j8-8ec0a7dba69d9a0751db5b3f4751da33 av_one_half  avia-builder-el-2  el_after_av_one_full  el_before_av_one_half  first flex_column_div av-zero-column-padding  column-top-margin'     ><section  class='av_textblock_section av-lt6y4iy5-6e1ee09cadb6f67ffed6f1e804f6e702 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><span>Les troubles psychiatriques li\u00e9s au stress, tels que la d\u00e9pression et l\u2019anxi\u00e9t\u00e9, figurent parmi ceux dont la pr\u00e9valence au cours de la vie est la plus \u00e9lev\u00e9e dans le monde et repr\u00e9sentent une charge soci\u00e9tale consid\u00e9rable <\/span><sup><a id=\"ref-link-section-d56601826e764\" title=\"Kessler, RC et al. Pr\u00e9valence au cours de la vie et distribution de l\u2019\u00e2ge de d\u00e9but des troubles DSM-IV dans la r\u00e9plication de la National Comorbidity Survey. Arch. Gen. Psychiatry 62, 593\u2013602 (2005).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR1\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\"><span>1<\/span><\/a><span> , <\/span><a id=\"ref-link-section-d56601826e764_1\" title=\"Collaborateurs GBD. Charge mondiale, r\u00e9gionale et nationale de 12 troubles mentaux dans 204 pays et territoires, 1990\u20132019 : une analyse syst\u00e9matique pour la Global Burden of Disease Study 2019. Lancet Psychiatry 9, 137\u2013150 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR2\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\"><span>2<\/span><\/a><span> , <\/span><a id=\"ref-link-section-d56601826e767\" title=\"Kessler, RC, Petukhova, M., Sampson, NA, Zaslavsky, AM &amp; Wittchen, HU Pr\u00e9valence sur 12 mois et au cours de la vie, et risque de morbidit\u00e9 \u00e0 vie des troubles anxieux et de l\u2019humeur aux \u00c9tats-Unis. Int. J. Methods Psychiatr. Res. 21, 169\u2013184 (2012).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR3\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 3\"><span>3<\/span><\/a><\/sup><span>  . Par cons\u00e9quent, comprendre les cons\u00e9quences biologiques du stress chronique constitue une voie importante pour \u00e9laborer de nouvelles strat\u00e9gies contre les troubles li\u00e9s au stress. Des donn\u00e9es de plus en plus nombreuses sugg\u00e8rent que les interactions cerveau\u2013intestin peuvent r\u00e9guler la r\u00e9ponse au stress  <\/span><sup><a id=\"ref-link-section-d56601826e771\" title=\"Menard, C. et al. Le stress social induit une pathologie neurovasculaire qui favorise la d\u00e9pression. Nat. Neurosci. 20, 1752\u20131760 (2017).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR4\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 4\"><span>4<\/span><\/a><\/sup><span> . Parall\u00e8lement, il a \u00e9t\u00e9 montr\u00e9 que le microbiote intestinal \u2013 la communaut\u00e9 de micro-organismes, dont des bact\u00e9ries, des virus, des arch\u00e9es, des protozoaires et des champignons, vivant dans l\u2019intestin \u2013 via l\u2019axe microbiote\u2013intestin\u2013cerveau <\/span> <sup><a id=\"ref-link-section-d56601826e775\" title=\"Collaborateurs GBD. Charge mondiale, r\u00e9gionale et nationale de 12 troubles mentaux dans 204 pays et territoires, 1990\u20132019 : une analyse syst\u00e9matique pour la Global Burden of Disease Study 2019. Lancet Psychiatry 9, 137\u2013150 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR2\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 2\"><span>2<\/span><\/a><a id=\"ref-link-section-d56601826e778\" title=\"Cryan, JF et al. L\u2019axe microbiote\u2013intestin\u2013cerveau. Physiol. Rev. 99, 1877\u20132013 (2019).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR5\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 5\"><\/a><\/sup><span> influence le d\u00e9veloppement et le fonctionnement des syst\u00e8mes immunitaire et nerveux<\/span><\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2labvo-f577fc243eb07fb44146a0a9c9926b7a\">\n.flex_column.av-2labvo-f577fc243eb07fb44146a0a9c9926b7a{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-2labvo-f577fc243eb07fb44146a0a9c9926b7a av_one_half  avia-builder-el-4  el_after_av_one_half  avia-builder-el-last  flex_column_div av-zero-column-padding  column-top-margin'     ><p><section  class='av_textblock_section av-lth07wvq-50077e5cf6d5af93b0a9ab4ea925e4e8 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Les bact\u00e9ries constituent la grande majorit\u00e9 et la capacit\u00e9 m\u00e9tabolique des micro-organismes cellulaires de l\u2019intestin et il a \u00e9t\u00e9 d\u00e9montr\u00e9 qu\u2019elles modulent les r\u00e9ponses au stress <sup><a id=\"ref-link-section-d56601826e782\" title=\"Foster, JA, Rinaman, L. &amp; Cryan, JF Stress et l\u2019axe intestin\u2013cerveau : r\u00e9gulation par le microbiome. Neurobiol. Stress 7, 124\u2013136 (2017).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR6\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 6\">6<\/a><\/sup> . Bien que moins \u00e9tudi\u00e9s, les virus intestinaux, compos\u00e9s majoritairement de bact\u00e9riophages (ou phages), infectent les bact\u00e9ries et peuvent se r\u00e9pliquer et les lyser, ou s\u2019int\u00e9grer dans le g\u00e9nome de leur h\u00f4te et se r\u00e9pliquer avec elles <sup><a id=\"ref-link-section-d56601826e786\" title=\"Lozupone, CA, Stombaugh, JI, Gordon, JI, Jansson, JK &amp; Knight, R. Diversit\u00e9, stabilit\u00e9 et r\u00e9silience du microbiote intestinal humain. Nature 489, 220\u2013230 (2012).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR7\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 7\">7<\/a> , <a id=\"ref-link-section-d56601826e789\" title=\"Shkoporov, AN et al. Le virome intestinal humain est extr\u00eamement diversifi\u00e9, stable et individuel. Cell Host Microbe 26, 527\u2013541.e5 (2019).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR8\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 8\">8<\/a><\/sup> . Ces phages peuvent moduler la structure et la fonction du microbiote et contribuer, au niveau de la communaut\u00e9, \u00e0 la diversit\u00e9, \u00e0 la stabilit\u00e9 et \u00e0 la r\u00e9silience du microbiote <sup><a id=\"ref-link-section-d56601826e794\" title=\"Shkoporov, AN, Turkington, CJ &amp; Hill, C. Interactions r\u00e9ciproques entre bact\u00e9riophages et bact\u00e9ries dans l\u2019intestin humain. Nat. Rev. Microbiol. 20, 737\u2013749 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR9\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 9\">9<\/a><\/sup>  <\/p>\n<p>Nathaniel L. Ritz ,Lorraine A. Draper ,Thomaz FS Bastiaanssen ,Christopher JR Turkington ,Veronica L. Peterson ,Marcel van de Wouw ,Klara Vlckova ,Christine F\u00fclling ,Katherine E. Guzzetta ,Aurelijus Burokas ,Hugh Harris ,Marion Dalmasso ,Fiona Crispie ,Paul D. Cotter ,Andrey N. Shkoporov ,Gerard M. Moloney ,Timothy G. Dinan ,Colin Hill &amp;John F. Cryan<\/p>\n<\/div><\/section><br \/>\n<div  class='avia-button-wrap av-lt6y5l18-fc2294e4d79ef99e1d9db787f3363b89-wrap avia-button-center  avia-builder-el-6  el_after_av_textblock  avia-builder-el-last '><a href='https:\/\/www.nature.com\/articles\/s41564-023-01564-y'  class='avia-button av-lt6y5l18-fc2294e4d79ef99e1d9db787f3363b89 av-link-btn avia-icon_select-no avia-size-small avia-position-center avia-color-theme-color'   aria-label=\"vers l\u2019\u00e9tude\"><span class='avia_iconbox_title' >vers l\u2019\u00e9tude<\/span><\/a><\/div><\/p><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":558,"featured_media":8484,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8941","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-unkategorisiert"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2022\/10\/phagen-1.jpg?fit=966%2C543&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/pazElU-2kd","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/users\/558"}],"replies":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/comments?post=8941"}],"version-history":[{"count":1,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8941\/revisions"}],"predecessor-version":[{"id":8945,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/posts\/8941\/revisions\/8945"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media\/8484"}],"wp:attachment":[{"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/media?parent=8941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/categories?post=8941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.phage.help\/fr\/wp-json\/wp\/v2\/tags?post=8941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}