{"id":8931,"date":"2024-03-07T10:07:57","date_gmt":"2024-03-07T09:07:57","guid":{"rendered":"https:\/\/www.phage.help\/senza-categoria\/il-viroma-intestinale-e-associato-a-cambiamenti-comportamentali-e-risposte-immunitarie-indotti-dallo-stress-nei-topi\/"},"modified":"2026-05-18T09:07:14","modified_gmt":"2026-05-18T07:07:14","slug":"il-viroma-intestinale-e-associato-a-cambiamenti-comportamentali-e-risposte-immunitarie-indotti-dallo-stress-nei-topi","status":"publish","type":"post","link":"https:\/\/www.phage.help\/it\/unkategorisiert\/il-viroma-intestinale-e-associato-a-cambiamenti-comportamentali-e-risposte-immunitarie-indotti-dallo-stress-nei-topi\/","title":{"rendered":"Il viroma intestinale \u00e8 associato a cambiamenti comportamentali e risposte immunitarie indotti dallo stress nei topi"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-32x6tg-e759e29a8e0eb5558b4bf7b3134992b3\">\n.flex_column.av-32x6tg-e759e29a8e0eb5558b4bf7b3134992b3{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-32x6tg-e759e29a8e0eb5558b4bf7b3134992b3 av_one_full  avia-builder-el-0  el_before_av_one_half  avia-builder-el-first  first flex_column_div av-zero-column-padding  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2\">\n.avia-image-container.av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2 av-styling- avia-align-center  avia-builder-el-1  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-3471 avia-img-lazy-loading-not-3471 avia_image ' src=\"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?fit=1600%2C400&ssl=1\" alt='' title='koli-bacteria'  height=\"400\" width=\"1600\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?w=1600&amp;ssl=1 1600w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=300%2C75&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=768%2C192&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=1030%2C258&amp;ssl=1 1030w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=1500%2C375&amp;ssl=1 1500w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=705%2C176&amp;ssl=1 705w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=450%2C113&amp;ssl=1 450w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-d13j8-8ec0a7dba69d9a0751db5b3f4751da33\">\n.flex_column.av-d13j8-8ec0a7dba69d9a0751db5b3f4751da33{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-d13j8-8ec0a7dba69d9a0751db5b3f4751da33 av_one_half  avia-builder-el-2  el_after_av_one_full  el_before_av_one_half  first flex_column_div av-zero-column-padding  column-top-margin'     ><section  class='av_textblock_section av-lt6y4iy5-6e1ee09cadb6f67ffed6f1e804f6e702 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><span>I disturbi psichiatrici legati allo stress, come la depressione e l&#8217;ansia, sono tra le patologie con la pi\u00f9 alta prevalenza nel corso della vita a livello mondiale e rappresentano un notevole carico sociale <\/span><sup><a id=\"ref-link-section-d56601826e764\" title=\"Kessler, RC et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62, 593\u2013602 (2005).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR1\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\"><span>1<\/span><\/a><span> , <\/span><a id=\"ref-link-section-d56601826e764_1\" title=\"Collaboratori, GMD Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry 9, 137\u2013150 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR2\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\"><span>2<\/span><\/a><span> , <\/span><a id=\"ref-link-section-d56601826e767\" title=\"Kessler, RC, Petukhova, M., Sampson, NA, Zaslavsky, AM &amp; Wittchen, HU Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int. J. Methods Psychiatr. Res. 21, 169\u2013184 (2012).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR3\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 3\"><span>3<\/span><\/a><\/sup><span>  . Pertanto, comprendere le conseguenze biologiche dello stress cronico \u00e8 una via importante per lo sviluppo di nuove strategie per i disturbi legati allo stress. Sempre pi\u00f9 prove suggeriscono che le interazioni cervello-intestino possano guidare la risposta allo stress   <\/span><sup><a id=\"ref-link-section-d56601826e771\" title=\"Menard, C. et al. Social stress induces neurovascular pathology promoting depression. Nat. Neurosci. 20, 1752\u20131760 (2017).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR4\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 4\"><span>4<\/span><\/a><\/sup><span> . Allo stesso tempo, \u00e8 stato dimostrato che il microbiota intestinale \u2013 la comunit\u00e0 di microrganismi, tra cui batteri, virus, archaea, protozoi e funghi che vivono nell&#8217;intestino \u2013 attraverso l&#8217;asse microbiota-intestino-cervello <\/span> <sup><a id=\"ref-link-section-d56601826e775\" title=\"Collaboratori, GMD Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry 9, 137\u2013150 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR2\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 2\"><span>2<\/span><\/a><a id=\"ref-link-section-d56601826e778\" title=\"Cryan, JF et al. The Microbiota-Gut-Brain Axis. Physiol. Rev. 99, 1877\u20132013 (2019).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR5\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 5\"><\/a><\/sup><span>  influenza lo sviluppo e la funzione del sistema immunitario e nervoso<\/span><\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2labvo-f577fc243eb07fb44146a0a9c9926b7a\">\n.flex_column.av-2labvo-f577fc243eb07fb44146a0a9c9926b7a{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-2labvo-f577fc243eb07fb44146a0a9c9926b7a av_one_half  avia-builder-el-4  el_after_av_one_half  avia-builder-el-last  flex_column_div av-zero-column-padding  column-top-margin'     ><p><section  class='av_textblock_section av-lth07wvq-50077e5cf6d5af93b0a9ab4ea925e4e8 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>I batteri costituiscono la stragrande maggioranza e la capacit\u00e0 metabolica dei microrganismi cellulari nell&#8217;intestino e hanno dimostrato di modulare le risposte allo stress <sup><a id=\"ref-link-section-d56601826e782\" title=\"Foster, JA, Rinaman, L. &amp; Cryan, JF Stress and the gut-brain axis: Regulation by the microbiome. Neurobiol. Stress 7, 124\u2013136 (2017).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR6\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 6\">6<\/a><\/sup> . Sebbene meno studiati, i virus intestinali, composti prevalentemente da batteriofagi (o fagi), infettano i batteri e possono replicarsi e lisarli oppure integrarsi nel genoma dell&#8217;ospite e replicarsi insieme a loro <sup><a id=\"ref-link-section-d56601826e786\" title=\"Lozupone, CA, Stombaugh, JI, Gordon, JI, Jansson, JK &amp; Knight, R. Diversity, stability and resilience of the human gut microbiota. Nature 489, 220\u2013230 (2012).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR7\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 7\">7<\/a> , <a id=\"ref-link-section-d56601826e789\" title=\"Shkoporov, AN et al. The Human Gut Virome Is Highly Diverse, Stable, and Individual. Cell Host Microbe 26, 527\u2013541.e5 (2019).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR8\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 8\">8<\/a><\/sup> . Questi fagi possono modulare la struttura e la funzione del microbiota e contribuire alla diversit\u00e0, stabilit\u00e0 e resilienza del microbiota a livello di comunit\u00e0 <sup><a id=\"ref-link-section-d56601826e794\" title=\"Shkoporov, AN, Turkington, CJ &amp; Hill, C. Mutualistic interplay between bacteriophages and bacteria in the human gut. Nat. Rev. Microbiol. 20, 737\u2013749 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR9\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 9\">9<\/a><\/sup>  <\/p>\n<p>Nathaniel L. Ritz, Lorraine A. Draper, Thomaz FS Bastiaanssen, Christopher JR Turkington, Veronica L. Peterson, Marcel van de Wouw, Klara Vlckova, Christine F\u00fclling, Katherine E. Guzzetta, Aurelijus Burokas, Hugh Harris, Marion Dalmasso, Fiona Crispie, Paul D. Cotter, Andrey N. Shkoporov, Gerard M. Moloney, Timothy G. Dinan, Colin Hill &amp; John F. Cryan<\/p>\n<\/div><\/section><br \/>\n<div  class='avia-button-wrap av-lt6y5l18-91bd331bd00c3d168b7d869e691308e2-wrap avia-button-center  avia-builder-el-6  el_after_av_textblock  avia-builder-el-last '><a href='https:\/\/www.nature.com\/articles\/s41564-023-01564-y'  class='avia-button av-lt6y5l18-91bd331bd00c3d168b7d869e691308e2 av-link-btn avia-icon_select-no avia-size-small avia-position-center avia-color-theme-color'   aria-label=\"vai allo studio\"><span class='avia_iconbox_title' >vai allo studio<\/span><\/a><\/div><\/p><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":558,"featured_media":8438,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8931","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-unkategorisiert"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2022\/10\/phagen-1.jpg?fit=966%2C543&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/pazElU-2k3","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/posts\/8931","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/users\/558"}],"replies":[{"embeddable":true,"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/comments?post=8931"}],"version-history":[{"count":1,"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/posts\/8931\/revisions"}],"predecessor-version":[{"id":8935,"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/posts\/8931\/revisions\/8935"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/media\/8438"}],"wp:attachment":[{"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/media?parent=8931"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/categories?post=8931"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.phage.help\/it\/wp-json\/wp\/v2\/tags?post=8931"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}