{"id":8914,"date":"2024-03-07T10:07:57","date_gmt":"2024-03-07T09:07:57","guid":{"rendered":"https:\/\/www.phage.help\/niet-gecategoriseerd\/het-darmviroom-is-geassocieerd-met-stressgerelateerde-gedragsveranderingen-en-immuunreacties-bij-muizen\/"},"modified":"2026-05-18T09:07:13","modified_gmt":"2026-05-18T07:07:13","slug":"het-darmviroom-is-geassocieerd-met-stressgerelateerde-gedragsveranderingen-en-immuunreacties-bij-muizen","status":"publish","type":"post","link":"https:\/\/www.phage.help\/nl\/niet-gecategoriseerd\/het-darmviroom-is-geassocieerd-met-stressgerelateerde-gedragsveranderingen-en-immuunreacties-bij-muizen\/","title":{"rendered":"Het darmviroom is geassocieerd met stressgerelateerde gedragsveranderingen en immuunreacties bij muizen"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-32x6tg-e759e29a8e0eb5558b4bf7b3134992b3\">\n.flex_column.av-32x6tg-e759e29a8e0eb5558b4bf7b3134992b3{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-32x6tg-e759e29a8e0eb5558b4bf7b3134992b3 av_one_full  avia-builder-el-0  el_before_av_one_half  avia-builder-el-first  first flex_column_div av-zero-column-padding  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2\">\n.avia-image-container.av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lt6y7gdy-cfc3176e44fd1ef34bb0a34161db75f2 av-styling- avia-align-center  avia-builder-el-1  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-3471 avia-img-lazy-loading-not-3471 avia_image ' src=\"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?fit=1600%2C400&ssl=1\" alt='' title='koli-bacteria'  height=\"400\" width=\"1600\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?w=1600&amp;ssl=1 1600w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=300%2C75&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=768%2C192&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=1030%2C258&amp;ssl=1 1030w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=1500%2C375&amp;ssl=1 1500w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=705%2C176&amp;ssl=1 705w, https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2018\/12\/koli-bacteria.jpg?resize=450%2C113&amp;ssl=1 450w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-d13j8-8ec0a7dba69d9a0751db5b3f4751da33\">\n.flex_column.av-d13j8-8ec0a7dba69d9a0751db5b3f4751da33{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-d13j8-8ec0a7dba69d9a0751db5b3f4751da33 av_one_half  avia-builder-el-2  el_after_av_one_full  el_before_av_one_half  first flex_column_div av-zero-column-padding  column-top-margin'     ><section  class='av_textblock_section av-lt6y4iy5-6e1ee09cadb6f67ffed6f1e804f6e702 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><span>Stressgerelateerde psychiatrische aandoeningen zoals depressie en angststoornissen behoren wereldwijd tot de hoogste levenslange prevalenties en vormen een aanzienlijke maatschappelijke last <\/span><sup><a id=\"ref-link-section-d56601826e764\" title=\"Kessler, RC et al. Levenslange prevalentie en verdeling van de aanvangsleeftijd van DSM-IV-aandoeningen in de replicatie van de National Comorbidity Survey. Arch. Gen. Psychiatry 62, 593\u2013602 (2005).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR1\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\"><span>1<\/span><\/a><span> , <\/span><a id=\"ref-link-section-d56601826e764_1\" title=\"Collaborators, GMD. Wereldwijde, regionale en nationale last van 12 psychische stoornissen in 204 landen en gebieden, 1990\u20132019: een systematische analyse voor de Global Burden of Disease Study 2019. Lancet Psychiatry 9, 137\u2013150 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR2\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\"><span>2<\/span><\/a><span> , <\/span><a id=\"ref-link-section-d56601826e767\" title=\"Kessler, RC, Petukhova, M., Sampson, NA, Zaslavsky, AM &amp; Wittchen, HU. Twaalfmaandelijkse en levenslange prevalentie en levenslang morbiditeitsrisico van angst- en stemmingsstoornissen in de Verenigde Staten. Int. J. Methods Psychiatr. Res. 21, 169\u2013184 (2012).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR3\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 3\"><span>3<\/span><\/a><\/sup><span>  . Daarom is het begrijpen van de biologische gevolgen van chronische stress een belangrijke weg bij de ontwikkeling van nieuwe strategie\u00ebn voor stressgerelateerde aandoeningen. Toenemend bewijs suggereert dat hersen-darm-interacties de reactie op stress kunnen sturen   <\/span><sup><a id=\"ref-link-section-d56601826e771\" title=\"Menard, C. et al. Sociale stress induceert neurovasculaire pathologie die depressie bevordert. Nat. Neurosci. 20, 1752\u20131760 (2017).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR4\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 4\"><span>4<\/span><\/a><\/sup><span> . Tegelijkertijd is aangetoond dat de darmmicrobiota \u2013 de gemeenschap van micro-organismen, waaronder bacteri\u00ebn, virussen, archaea, protozoa en schimmels, die in de darm leven \u2013 via de microbiota-darm-hersen-as <\/span> <sup><a id=\"ref-link-section-d56601826e775\" title=\"Collaborators, GMD. Wereldwijde, regionale en nationale last van 12 psychische stoornissen in 204 landen en gebieden, 1990\u20132019: een systematische analyse voor de Global Burden of Disease Study 2019. Lancet Psychiatry 9, 137\u2013150 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR2\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 2\"><span>2<\/span><\/a><a id=\"ref-link-section-d56601826e778\" title=\"Cryan, JF et al. De microbiota-darm-hersen-as. Physiol. Rev. 99, 1877\u20132013 (2019).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR5\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 5\"><\/a><\/sup><span>  de ontwikkeling en functie van het immuun- en zenuwstelsel be\u00efnvloedt<\/span><\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2labvo-f577fc243eb07fb44146a0a9c9926b7a\">\n.flex_column.av-2labvo-f577fc243eb07fb44146a0a9c9926b7a{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-2labvo-f577fc243eb07fb44146a0a9c9926b7a av_one_half  avia-builder-el-4  el_after_av_one_half  avia-builder-el-last  flex_column_div av-zero-column-padding  column-top-margin'     ><p><section  class='av_textblock_section av-lth07wvq-50077e5cf6d5af93b0a9ab4ea925e4e8 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Bacteri\u00ebn vormen de overgrote meerderheid en metabole capaciteit van de cellulaire micro-organismen in de darm en moduleren aantoonbaar stressreacties <sup><a id=\"ref-link-section-d56601826e782\" title=\"Foster, JA, Rinaman, L. &amp; Cryan, JF. Stress en de darm-hersen-as: regulatie door het microbioom. Neurobiol. Stress 7, 124\u2013136 (2017).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR6\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 6\">6<\/a><\/sup> . Hoewel minder onderzocht, infecteren darmvirussen, die overwegend uit bacteriofagen (of fagen) bestaan, bacteri\u00ebn en kunnen ze zich vermenigvuldigen en lyseren of integreren in hun gastheergenoom en zich ernaast vermenigvuldigen <sup><a id=\"ref-link-section-d56601826e786\" title=\"Lozupone, CA, Stombaugh, JI, Gordon, JI, Jansson, JK &amp; Knight, R. Diversiteit, stabiliteit en veerkracht van de menselijke darmmicrobiota. Nature 489, 220\u2013230 (2012).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR7\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 7\">7<\/a> , <a id=\"ref-link-section-d56601826e789\" title=\"Shkoporov, AN et al. Het menselijke darmviroom is uiterst divers, stabiel en individueel. Cell Host Microbe 26, 527\u2013541.e5 (2019).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR8\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 8\">8<\/a><\/sup> . Deze fagen kunnen de structuur en functie van de microbiota moduleren en bijdragen aan de diversiteit, stabiliteit en veerkracht van de microbiota op gemeenschapsniveau <sup><a id=\"ref-link-section-d56601826e794\" title=\"Shkoporov, AN, Turkington, CJ &amp; Hill, C. Wederzijdse interactie tussen bacteriofagen en bacteri\u00ebn in de menselijke darm. Nat. Rev. Microbiol. 20, 737\u2013749 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41564-023-01564-y#ref-CR9\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Referenz 9\">9<\/a><\/sup>  <\/p>\n<p>Nathaniel L. Ritz, Lorraine A. Draper, Thomaz FS Bastiaanssen, Christopher JR Turkington, Veronica L. Peterson, Marcel van de Wouw, Klara Vlckova, Christine F\u00fclling, Katherine E. Guzzetta, Aurelijus Burokas, Hugh Harris, Marion Dalmasso, Fiona Crispie, Paul D. Cotter, Andrey N. Shkoporov, Gerard M. Moloney, Timothy G. Dinan, Colin Hill &amp; John F. Cryan<\/p>\n<\/div><\/section><br \/>\n<div  class='avia-button-wrap av-lt6y5l18-709bb7dbec9277ca51829bc733071b52-wrap avia-button-center  avia-builder-el-6  el_after_av_textblock  avia-builder-el-last '><a href='https:\/\/www.nature.com\/articles\/s41564-023-01564-y'  class='avia-button av-lt6y5l18-709bb7dbec9277ca51829bc733071b52 av-link-btn avia-icon_select-no avia-size-small avia-position-center avia-color-theme-color'   aria-label=\"Naar de studie\"><span class='avia_iconbox_title' >Naar de studie<\/span><\/a><\/div><\/p><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":558,"featured_media":8465,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[211],"tags":[],"class_list":["post-8914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-niet-gecategoriseerd"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.phage.help\/wp-content\/uploads\/2022\/10\/phagen-1.jpg?fit=966%2C543&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/pazElU-2jM","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/posts\/8914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/users\/558"}],"replies":[{"embeddable":true,"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/comments?post=8914"}],"version-history":[{"count":10,"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/posts\/8914\/revisions"}],"predecessor-version":[{"id":8948,"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/posts\/8914\/revisions\/8948"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/media\/8465"}],"wp:attachment":[{"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/media?parent=8914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/categories?post=8914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.phage.help\/nl\/wp-json\/wp\/v2\/tags?post=8914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}