Archive for year: 2021

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Phage therapy for bacterial prostatitis

Patients with chronic bacterial prostatitis often face a double problem: they suffer not only from the symptoms of the disease, but also from the difficulties in treating the infection. The lining of the prostate is impermeable to many classes…

One Step Closer to Phage Therapy for Antibiotic-Resistant Infections

Most phage therapy experiments begin and end in vitro—in cultures of target bacteria. Such conditions have little to do with the actual situation in humans and animals. Therefore, scientists* have created a model that can simulate the microenvironment…

Tens of thousands of phage species inhabit the human gut

Following the analysis of human feces, scientists identified 54,118 types of viruses, most of which turned out to be bacterial viruses – bacteriophages Recently, there has been growing interest among scientists in the human microbiota –…

Clinical trials for phage therapy in urinary tract infections have begun

Phase I/II clinical trials have begun in the USA to evaluate the efficacy and safety of personalized phage preparations in patients with urinary tract infections (UTIs) caused by multi-drug resistant bacteria. The tests were initiated by Adaptive…

Mycobacteriophages: a cocktail against tuberculosis

To date, the potential of bacteriophages that destroy mycobacteria in combating tuberculosis has been demonstrated—namely in diagnosing the disease, preventing infections, and treatment. However, phage therapy for tuberculosis remains a challenging…
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Phage Therapy for Knee Prosthesis Infection

Bacteriophages show great potential in treating patients with prosthetic joint infections, as they act synergistically with antibiotics and destroy biofilms. The journal Frontiers in Medicine published a clinical case on the treatment of a recurrent…

Bacteriophages help with the early detection of Lyme disease

A new PCR test for the early detection of Lyme disease has been proposed. The test identifies a gene that does not belong to the bacterium that causes the disease, but to a bacteriophage specific to it. If a bacteriophage is found, there is…
Antibiotic Resistance in the Arctic
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Bacteriophages in the Treatment of Infected Diabetic Foot: State of the Art

Jessica Sacher, Editor-in-Chief, Online Weekly Capsid & Tail, discussed the challenges of treating infected foot ulcers in patients with diabetes mellitus and the potential of phage therapy for this pathology Every 20 seconds, a person…
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Phage therapy is being tested for the treatment of ventilator-associated pneumonia.

At the annual Congress on Inhalation and Respiratory Drug Delivery (April 20–21, 2021), the results of preclinical studies of an inhaled phage medicine for the treatment of ventilator-associated pneumonia (VAP) will be presented. VAP is one…

Bacteriophages Influence the Gut Flora

"The ecosystem in our gut is even more complex than one might imagine, a study clarifies: It is teeming not only with bacteria but also with the viruses that infect them. Through genetic analyses, researchers have identified thousands of new…

Synthetic Bacteriophage Created to Attack Pseudomonas aeruginosa Bacteria

For the first time, scientists "manually" synthesized bacteriophages with a reduced genome that lyse various strains of Pseudomonas aeruginosa. This achievement could be the first step toward creating new antibacterial agents. Bacteriophages…

Bacteriophages have restored the sensitivity of bacteria to antibiotics

Antibiotic-resistant Acinetobacter baumannii bacteria acquired antibiotic sensitivity after treatment with bacteriophages. It was found that in an attempt to escape the bacteriophages, the bacteria mutated in such a way that they became susceptible…