Therapeutic Potential of Phages in Autoimmune Liver Diseases

Autoimmune liver disease (ALD) presents a significant medical challenge, as there is a considerable number of patients for whom current therapy offers questionable or no benefit, yet side effects can be severe, including the development of malignancy. Bacterial viruses (phages) are increasingly recognized as immunomodulators that contribute to immune homeostasis and curb inflammation. Accumulating data suggest that phages may be beneficial in the immunotherapy of ALD. Phages have been shown to downregulate the expression and/or production and activity of factors associated with liver damage [reactive oxygen species, Toll-like receptor (TLR) 4 activation, nuclear factor kappa B (NF-KB) activation,

A. Górski, E. Jończyk-Matysiak, M. Łusiak-Szelachowska, B. Weber-Dąbrowska, R. Międzybrodzki and J. Borysowski
Therapeutic Potential of Phages in Autoimmune Liver Diseases
Clin Exp Immunol. 2018 Apr; 192 (1): 1–6. doi: 10.1111 / cei.13092