Bacteriophages in urology: application experience in Russia
In February 2020, a scientific and practical conference with international participation took place in Moscow: “Rational pharmacotherapy in urology – 2020”. Professor Tamara Perepanova, MD, presented a program report on clinical recommendations for antimicrobial therapy and the prevention of infections of the kidneys, urinary tract, and male genital organs. She is the Head of the Department of Urology and Interventional Radiology, named after N.A. Lopatkin, Chair of the Moscow Society of Urologists, Chair of the IGO “Rational Pharmacotherapy in Urology,” and a board member of the European Section for Infections in Urology of the European Association of Urology. In particular, Professor Perepanova noted that a major problem in urology is the increase in antibiotic resistance of uropathogens, both in outpatient and hospital settings. The search for alternative means for the prevention and treatment of urinary tract infections is ongoing.
The search for alternative active substances for the prevention and treatment of urinary tract infections has not yet concluded. Professor T.S. Perepanova presented the results of a study on the effectiveness of using purified polyvalent pyobacteriophages for the treatment and prevention of infectious complications following percutaneous nephrolithotripsy compared to antibiotic prophylaxis. Prior to percutaneous nephrolithotripsy, 30 patients received pyobacteriophages and another 30 patients received ciprofloxacin. Additionally, in the first group, to counteract biofilm formation, urethral catheters were immersed in a solution of pyobacteriophages (for 30 minutes). This did not yield a significant bacteriological effect, as biofilms still formed on the catheters. However, live bacteriophages were found in two biofilms, which requires further investigation. A comparative analysis showed a decrease in the incidence of systemic inflammatory response syndrome in the group treated with bacteriophages compared to the group receiving antibiotics, and an equal effect of treatment and prevention on the seventh day after surgery. Thus, the purified multivalent drug pyobacteriophage can be used to prevent and treat infectious and inflammatory complications of percutaneous nephrolithotripsy as an alternative to antibiotics. To improve antimicrobial efficacy, constant monitoring of the sensitivity of microorganisms to bacteriophage preparations and regular updating of the bacteriophage preparations against pathogens of a specific hospital or patient are required.
Machine translation of the source:
https://umedp.ru/articles/farmakoterapiya_urologicheskikh_zabolevaniy_chto_novogo_xiv_vserossiyskaya_nauchnoprakticheskaya_kon.html
