Archive for category: Bactériophages

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Phages are safe when taken orally.

Antibiogram & phagogram

Bacteriophages targeting microbiota alleviate nonalcoholic fatty liver disease.

Bacteriophages targeting microbiota alleviate nonalcoholic fatty liver disease caused by high-alcohol-producing Klebsiella pneumoniae. Previous studies have shown that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the gut microbiome…

Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions

Acne vulgaris is a common inflammatory skin disease caused by neutrophils, in which Cutibacterium acnes (C. acnes) is known to play a key role. For decades, antibiotics have been widely used to treat acne vulgaris, which inevitably leads to…

Successful treatment of a chronically infected and occluded aortobifemoral Dacron® bypass with bacteriophages (Snipha360)

Objectives: Graft infections are serious and feared complications in vascular surgery. Surgical resection of infected aortic grafts is associated with high mortality and morbidity. Therefore, alternatives to inadequate antibiotic treatment and…

Hope for Healing – Phage Therapy in Georgia

Can Dieter Offermann's knee still be saved? The 60-year-old is placing a lot of hope in a procedure that has almost been forgotten here, yet could simultaneously solve a major problem in Western medicine.

The new weapon in the fight against multidrug-resistant bacteria?

Antibiotics are increasingly failing to combat germs because bacteria have become resistant. The consequence: wounds that do not heal or life-threatening infections that cannot be controlled. New solutions are urgently being sought. Bacteriophages…

Phages Help with “Nightmare” Infections

Bacterial pathogens are increasingly failing to respond to antibiotics. In such cases, phage therapy can sometimes help, as a study demonstrates. A clinical trial is currently being prepared in Germany. Phage therapy can help combat difficult-to-treat…

Phages: Bacteria-Eaters from Georgia as Tomorrow’s Medicine

What to do when antibiotics no longer work? Patients from around the world travel to Georgia to receive treatment with bacteriophages. Phage therapy is now also available in Belgium. Tanja Diederen from near Maastricht in the Netherlands…

When viruses save lives

According to the World Health Organization, antibiotic resistance is one of the greatest dangers and challenges facing humanity. The French research project PHAG-ONE is therefore trying to develop an alternative to antibiotics. It relies on…

Bacteriophages instead of antibiotics

Colds, diarrhea, pneumonia: Bacteriophages could, in principle, be used against any infection caused by bacteria, said microbiologist Wolfgang Bayer on Dlf. However, as long as antibiotics generate more revenue for the pharmaceutical industry,…

Phage therapy for bacterial prostatitis

Patients with chronic bacterial prostatitis often face a double problem: they suffer not only from the symptoms of the disease, but also from the difficulties in treating the infection. The lining of the prostate is impermeable to many classes…

One Step Closer to Phage Therapy for Antibiotic-Resistant Infections

Most phage therapy experiments begin and end in vitro—in cultures of target bacteria. Such conditions have little to do with the actual situation in humans and animals. Therefore, scientists* have created a model that can simulate the microenvironment…

Tens of thousands of phage species inhabit the human gut

Following the analysis of human feces, scientists identified 54,118 types of viruses, most of which turned out to be bacterial viruses – bacteriophages Recently, there has been growing interest among scientists in the human microbiota –…

Clinical trials for phage therapy in urinary tract infections have begun

Phase I/II clinical trials have begun in the USA to evaluate the efficacy and safety of personalized phage preparations in patients with urinary tract infections (UTIs) caused by multi-drug resistant bacteria. The tests were initiated by Adaptive…

Mycobacteriophages: a cocktail against tuberculosis

To date, the potential of bacteriophages that destroy mycobacteria in combating tuberculosis has been demonstrated—namely in diagnosing the disease, preventing infections, and treatment. However, phage therapy for tuberculosis remains a challenging…
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Phage Therapy for Knee Prosthesis Infection

Bacteriophages show great potential in treating patients with prosthetic joint infections, as they act synergistically with antibiotics and destroy biofilms. The journal Frontiers in Medicine published a clinical case on the treatment of a recurrent…

Bacteriophages help with the early detection of Lyme disease

A new PCR test for the early detection of Lyme disease has been proposed. The test identifies a gene that does not belong to the bacterium that causes the disease, but to a bacteriophage specific to it. If a bacteriophage is found, there is…
Antibiotic Resistance in the Arctic
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Bacteriophages in the Treatment of Infected Diabetic Foot: State of the Art

Jessica Sacher, Editor-in-Chief, Online Weekly Capsid & Tail, discussed the challenges of treating infected foot ulcers in patients with diabetes mellitus and the potential of phage therapy for this pathology Every 20 seconds, a person…