Archive for category: Bactériophages

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Phage therapy is being tested for the treatment of ventilator-associated pneumonia.

At the annual Congress on Inhalation and Respiratory Drug Delivery (April 20–21, 2021), the results of preclinical studies of an inhaled phage medicine for the treatment of ventilator-associated pneumonia (VAP) will be presented. VAP is one…

Bacteriophages Influence the Gut Flora

"The ecosystem in our gut is even more complex than one might imagine, a study clarifies: It is teeming not only with bacteria but also with the viruses that infect them. Through genetic analyses, researchers have identified thousands of new…

Synthetic Bacteriophage Created to Attack Pseudomonas aeruginosa Bacteria

For the first time, scientists "manually" synthesized bacteriophages with a reduced genome that lyse various strains of Pseudomonas aeruginosa. This achievement could be the first step toward creating new antibacterial agents. Bacteriophages…

Bacteriophages have restored the sensitivity of bacteria to antibiotics

Antibiotic-resistant Acinetobacter baumannii bacteria acquired antibiotic sensitivity after treatment with bacteriophages. It was found that in an attempt to escape the bacteriophages, the bacteria mutated in such a way that they became susceptible…

Kidney Transplant Patient with Recurring Infections Gets Viral Help

Maria Madrigal was born with polycystic kidney disease, although she did not know she had this hereditary condition until adulthood, when growing cysts caused organ failure. Initially, dialysis helped, but eventually Madrigal needed a donor…

Antibiotics in children under 2 years of age can lead to chronic diseases

Children under 2 years of age who take antibiotics have a higher risk of asthma, respiratory allergies, eczema, celiac disease, obesity, and attention-deficit hyperactivity disorder, according to a study co-authored by researchers from the Mayo…

Breast Milk Influences the Virome / Bacteriophages in the Newborn Gut

The gut of healthy human newborns is normally free of viruses at birth but is rapidly colonized, leading in some cases to gastrointestinal diseases. Here we show that the establishment of the viral community in newborns occurs in distinct stages.…

Phage therapy for the treatment of a virulent Klebsiella pneumoniae infection in a mouse model

Objectives Klebsiella pneumoniae is an important emerging pathogen in humans and animals with serious clinical consequences. The increased use of antibiotics has promoted the emergence of carbapenem-resistant and β-lactamase (ESBL)-producing…
Antibiotic Resistance in the Arctic

Phage cocktail for diabetic wound infections caused by MRSA

Diabetic foot ulcer (DFU) is a serious complication of diabetes mellitus. Antibiotic-resistant Staphylococcus aureus is frequently isolated from DFU infections. Bacteriophages (phages) represent an alternative or complementary treatment to antibiotic…

Fighting Infections in Aquaculture – Opportunities and Challenges of Phage Therapy

Phage therapy, a promising alternative to antimicrobial treatment of bacterial diseases, is becoming increasingly popular, primarily due to growing awareness of antibiotic resistance and limitations in the use of antibiotics. In recent years,…

Bacteriophage therapy for critical infections related to cardiothoracic surgery

Bacterial resistance to conventional antibiotic therapy represents an increasingly significant challenge for human health worldwide. The objective is to investigate whether bacteriophage therapy could supplement conventional antibiotic therapy…

Bacteriophage therapy for a chronic MRSA prosthetic joint infection

This is the case of a 72-year-old man with a chronic methicillin-resistant Staphylococcus aureus prosthetic joint infection. After the third intravenous bacteriophage therapy dose, an unusual, reversible transaminitis led to the discontinuation…
Phage Therapy for Urinary Tract Infection

Bacteriophage therapy for a chronic MRSA prosthetic joint infection

This is the case of a 72-year-old man with a chronic methicillin-resistant Staphylococcus aureus prosthetic joint infection. After the third dose of intravenous bacteriophage therapy, an unusual reversible transaminitis led to the discontinuation…
Phage Therapy for Sinusitis

Bacteriophage Treatment for Chronic Rhinosinusitis in EPOS-2020

The European Rhinologic Society updated the guidelines for the treatment of acute and chronic rhinosinusitis and nasal polyps - EPOS-2020. Bacteriophage treatment was also mentioned here. Excerpt from EPOS-2020 "As antibiotic treatment may…

Hiding bacteriophages in liposomes like a Trojan horse

The liposome can become a "Trojan horse" that helps bacteriophages enter the cell and destroy intracellular bacterial pathogens Recently, a * microfluidic technology for encapsulating bacteriophages in liposomes with a size of 100 to 300 nm…
Phage Therapy for Urinary Tract Infection

Scientists discover new antibiotic with artificial intelligence

In a world first, scientists have discovered a new type of antibiotic using artificial intelligence (AI). It was announced by experts as a significant breakthrough in the fight against the growing problem of drug resistance. Using a powerful…

Scientists discover new antibiotic with artificial intelligence

In a world first, scientists have discovered a new type of antibiotic with the help of artificial intelligence (AI). It has been hailed by experts as a major breakthrough in the fight against the growing problem of drug resistance. Using a powerful…

Phage therapy: the forgotten therapy in Brazil

The world knows little about the therapeutic use of bacteriophages in South America. To remedy this situation, The Lancet published a comprehensive overview of the history of phage therapy in Brazil, whose heyday was the "golden age" of bacteriophages…
Phage Therapy for Urinary Tract Infection

Bacteriophages in urology: application experience in Russia

In February 2020, a scientific and practical conference with international participation took place in Moscow: "Rational pharmacotherapy in urology - 2020". Professor Tamara Perepanova, MD, presented a program report on clinical recommendations…
Phage Therapy for Urinary Tract Infection

Bacteriophages in Urology: Application Experience in Russia

In February 2020, a scientific and practical conference with international participation "Rational Pharmacotherapy in Urology - 2020" took place in Moscow. Dr. med. prepared a program report on clinical recommendations for antimicrobial therapy…